Cause of recurrent missed abortion at 10 weeks –
## **Core Concept**
The question pertains to the etiology of recurrent missed abortion, specifically at 10 weeks of gestation. Missed abortion refers to the demise of the fetus without immediate expulsion from the uterus. Recurrent missed abortion implies repeated episodes, suggesting an underlying cause that predisposes to this condition.
## **Why the Correct Answer is Right**
The correct answer, **Luteal phase defect**, is a condition where the endometrium does not develop normally in response to progesterone, leading to inadequate implantation or early pregnancy support. This defect can cause recurrent early pregnancy loss, including missed abortion, as the endometrium may not provide a suitable environment for embryonic development.
## **Why Each Wrong Option is Incorrect**
- **Option A:** While chromosomal abnormalities are a common cause of miscarriages, they are less likely to cause recurrent missed abortions at the same gestational age without other underlying issues.
- **Option B:** Uterine anomalies can cause pregnancy complications, including miscarriages, but are not as directly linked to recurrent missed abortion at 10 weeks as luteal phase defects.
- **Option C:** Antiphospholipid syndrome is a known cause of recurrent pregnancy loss but typically presents with a broader range of symptoms and complications beyond just missed abortion.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that luteal phase defect is often associated with progesterone insufficiency or resistance. Clinicians may diagnose this condition through endometrial biopsy or progesterone level assessments. Treatment often involves progesterone supplementation.
## **Correct Answer:** . Luteal phase defect