**Core Concept**
Cartilage and bone are two types of connective tissue that differ in their composition, structure, and function. **Cartilage** is a flexible, yet strong tissue that provides support and cushioning, while **bone** is a rigid, calcified tissue that provides structural support. The key difference between cartilage and bone lies in their ability to grow and increase in size.

**Why the Correct Answer is Right**
The correct answer is related to the unique properties of cartilage. Cartilage can increase in size by **appositional growth**, where new cartilage is added to the surface of existing cartilage, or by **interstitial growth**, where new cartilage is formed within the existing tissue. This is in contrast to bone, which can only increase in size by **appositional growth**.

**Why Each Wrong Option is Incorrect**
**Option A:** is incorrect because it is not a recognized method of cartilage growth.
**Option B:** is incorrect because it is not a recognized method of cartilage growth.
**Option C:** is incorrect because it is not a recognized method of cartilage growth.
**Option D:** is incorrect because it is not the only method of cartilage growth.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that cartilage has limited ability to repair itself, and damage to cartilage can lead to conditions such as **osteoarthritis**. Understanding the differences between cartilage and bone is crucial for diagnosing and managing various musculoskeletal disorders.

**Correct Answer:** D. appositional and interstitial growth