Cardiotoxicity of bupivacaine –

Correct Answer: Depressed pacemaker activity
Description: Ans. is 'a' i.e., Depressed pacemaker activity o Local anaesthetics block cardiac sodium channels and thus depress abnormal cardiac pacemaker activity, excitability, and conduction. At extremely high concentrations, local anaesthetics can also block calcium channels.
Category: Pharmacology
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