In which of the following types of Carcinoma Breast, Comedo growth pattern in seen ?
**Core Concept**
Ductal carcinoma in situ (DCIS) is a type of non-invasive breast cancer where malignant cells are confined to the milk ducts, and have not invaded surrounding tissues. The comedo subtype of DCIS is characterized by a high-grade, high-risk pattern of growth.
**Why the Correct Answer is Right**
The comedo subtype of DCIS is named for its resemblance to the comedones or blackheads found in acne. This type of DCIS is characterized by a high-grade, high-risk pattern of growth, with large, pleomorphic cells and a high degree of cellular atypia. The comedo subtype is often associated with a rapid growth rate and a higher risk of local recurrence.
**Why Each Wrong Option is Incorrect**
* **Option B:** Medullary carcinoma is a rare subtype of invasive ductal carcinoma, characterized by a distinct border and a high density of lymphocytes. It is not typically associated with the comedo growth pattern.
* **Option C:** Lobular carcinoma in situ (LCIS) is a type of non-invasive breast cancer that affects the lobules of the breast, rather than the ducts. While LCIS can increase the risk of developing invasive breast cancer, it is not typically associated with the comedo growth pattern.
* **Option D:** Infiltrating lobular carcinoma is a type of invasive breast cancer that originates in the lobules of the breast. It is not typically associated with the comedo growth pattern.
**Clinical Pearl / High-Yield Fact**
The comedo subtype of DCIS is often associated with a high risk of local recurrence and may require more aggressive treatment, such as mastectomy or radiation therapy.
**Correct Answer:**
✓ Correct Answer: A. Ductal carcinoma in situ