Carbimazole as compared to propylthiouracil:
Correct Answer: Does not inhibit peripheral conversion of T4 to T3
Description: (Ref: KDT 6/e p250) Carbimazole Propylthiouracil Produces an active metabolite, methimazole No active metabolite Less plasma protein binding (PPB) More PPB Crosses placenta Does not cross placenta More potent Less potent Does not inhibit 5'-deiodinase Inhibits 5'-deiodinase
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