Captopril can cause all Except:
**Core Concept**
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used primarily to treat hypertension and heart failure. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure.
**Why the Correct Answer is Right**
Captopril can cause a dry cough due to the accumulation of bradykinin, a peptide that is also broken down by ACE. This is because ACE is involved in the degradation of bradykinin, and when ACE is inhibited, bradykinin levels increase, leading to coughing. Additionally, captopril can cause hyperkalemia, hypotension, and renal impairment in susceptible individuals.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a known side effect of captopril. While it is true that ACE inhibitors can cause a range of side effects, hypertriglyceridemia is not typically associated with captopril.
**Option B:** While captopril can cause renal impairment, especially in patients with pre-existing kidney disease, it is not the only option listed that is a potential side effect.
**Option C:** Captopril can indeed cause a dry cough, as mentioned earlier.
**Clinical Pearl / High-Yield Fact**
It is essential to note that ACE inhibitors like captopril can cause a dry cough in up to 20% of patients, making it a common side effect that clinicians should be aware of.
**Correct Answer: A. Hypertriglyceridemia**