A deficiency of which of the following cells can predispose to candidiasis
## **Core Concept**
The question tests the understanding of the immune system's role in defending against fungal infections, specifically candidiasis. Candidiasis is a type of fungal infection caused by Candida species, commonly affecting the mucous membranes and skin. The immune cells responsible for controlling fungal infections are primarily those involved in cell-mediated immunity.
## **Why the Correct Answer is Right**
The correct answer, **T cells (more specifically, CD4+ T cells)**, is right because these cells play a crucial role in cell-mediated immunity, which is essential for controlling fungal infections, including candidiasis. A deficiency in CD4+ T cells, often seen in HIV/AIDS patients, significantly impairs the body's ability to fight off opportunistic infections like candidiasis.
## **Why Each Wrong Option is Incorrect**
- **Option A:** While B cells and their produced antibodies are crucial for combating many types of infections, they are not the primary immune cells responsible for defense against fungal infections like candidiasis. B cells are more involved in humoral immunity.
- **Option B:** Neutrophils are a type of white blood cell that plays a key role in the defense against bacterial and fungal infections through phagocytosis. However, a deficiency in neutrophils (neutropenia) more commonly predisposes individuals to bacterial and certain fungal infections, but the specific susceptibility to candidiasis is more closely related to impaired cell-mediated immunity.
- **Option D:** Eosinophils are involved in combating parasitic infections and in allergic reactions. They are not the primary cells responsible for defending against candidiasis.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that patients with HIV/AIDS, who often have low CD4+ T cell counts, are particularly susceptible to opportunistic infections, including candidiasis. This association highlights the importance of cell-mediated immunity in controlling fungal infections.
## **Correct Answer:** . T cells