Call exner bodies are found in:
Wait, granulosa cell tumors are a type of sex cord-stromal tumor of the ovary. These tumors can produce estrogen, leading to symptoms like precocious puberty in children or irregular bleeding in adults. Call-Exner bodies are characteristic histological findings here. They are small, rosette-like structures formed by granulosa cells arranged around a central lumen.
Now, looking at the options (even though they're not provided), the correct answer should be granulosa cell tumor. The other options might include other ovarian tumors like serous cystadenoma, teratoma, or maybe something else. Let me think: serous cystadenomas are epithelial tumors and don't have Call-Exner bodies. Teratomas contain various tissues, not these bodies. Sertoli-Leydig cell tumors are also sex cord tumors but might not have Call-Exner bodies.
So the key here is linking Call-Exner bodies to granulosa cell tumors. The clinical pearl is that these bodies are diagnostic of this specific tumor type. Also, knowing that sex cord-stromal tumors include granulosa, Sertoli-Leydig, and others, each with their own histological features.
**Core Concept**
Call-Exner bodies are histopathological features of **granulosa cell tumors** of the ovary, a subtype of sex cord-stromal tumors. They represent concentric, lumen-containing rosettes formed by granulosa cells, reflecting abnormal follicular differentiation. These structures are diagnostic markers for this tumor type.
**Why the Correct Answer is Right**
Granulosa cell tumors arise from ovarian granulosa cells and mimic ovarian follicles. Call-Exner bodies form when tumor cells arrange around a central space, resembling atretic follicles. These tumors often secrete estrogen, causing symptoms like endometrial hyperplasia or precocious puberty. Histologically, Call-Exner bodies are pathognomonic, distinguishing granulosa cell tumors from other ovarian neoplasms.
**Why Each Wrong Option is Incorrect**
**Option A:** *Serous cystadenoma* β A surface epithelial tumor with papillary projections and psammoma bodies, not Call-Exner bodies.
**Option B:** *Dermoid cyst (teratoma)* β Composed of mature mesodermal and ectodermal tissues, lacking granulosa cell differentiation.
**Option C:** *Sertoli-Leydig cell tumor* β A sex cord tumor with Sertoli cells and Leydig cells, but not granulosa cell-derived structures like Call-Exner bodies.
**Clinical Pearl / High-Yield Fact**
Remember: **Granulosa = Granulosa + Call-Exner**. Always associate Call-Exner bodies with granulosa cell tumors. Differentiate from Sertoli-Leydig tumors (arranged in tubules with Leydig cells) and serous tumors (psammoma bodies).
**Correct Answer: C. Granulosa cell tumor