**Core Concept:**
In the context of a patient with emphysema and hypertension, the choice of antihypertensive medication should take into account the patient's comorbidities and potential side effects. Emphysema patients often have a reduced cardiac output and a high risk of hypotension, making beta antagonists an appropriate choice.
**Why the Correct Answer is Right:**
1. The patient has been prescribed various antihypertensive agents but experiences severe side effects, which rules out options A, B, and D.
2. Angiotensin converting enzyme inhibitors (A) and calcium channel blockers (D) are contraindicated in patients with severe chronic obstructive pulmonary disease (COPD) due to their risk of inducing hypotension, bronchoconstriction, and worsening of respiratory symptoms.
3. Diuretics (B) can cause electrolyte imbalances, dehydration, and worsening of respiratory symptoms in the patient with COPD.
4. Beta antagonists (C) are a better choice for this patient because they are less likely to cause hypotension and worsen respiratory symptoms due to their selective action on beta1 receptors, sparing the beta2 receptors responsible for bronchodilation in COPD patients.
**Why Each Wrong Option is Incorrect:**
A. Angiotensin converting enzyme inhibitors (A) and calcium channel blockers (D) are contraindicated in patients with severe COPD due to their risk of inducing hypotension, bronchoconstriction, and worsening of respiratory symptoms.
B. Diuretics (B) can cause electrolyte imbalances, dehydration, and worsening of respiratory symptoms in the patient with COPD.
C. Beta antagonists (C) are a better choice for this patient because they are less likely to cause hypotension and worsen respiratory symptoms due to their selective action on beta1 receptors, sparing the beta2 receptors responsible for bronchodilation in COPD patients.
**Clinical Pearl:**
In patients with COPD, beta receptor antagonists are a safer choice for controlling hypertension, as they selectively inhibit beta1 receptors, sparing the beta2 receptors responsible for bronchodilation. This ensures that the patient's respiratory symptoms are not worsened.
**Correct Answer:**
C. Beta antagonists (C) are the appropriate choice for this patient.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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