Burkitt’s lymphoma arises from –
**Core Concept**
Burkitt's lymphoma is a type of aggressive B-cell non-Hodgkin lymphoma characterized by its rapid growth and high mitotic rate. It is associated with a translocation involving the MYC gene, which plays a crucial role in cell proliferation and apoptosis.
**Why the Correct Answer is Right**
Burkitt's lymphoma typically arises from germinal center B cells, which are a type of immune cell responsible for producing antibodies. The translocation t(8;14)(q24;q32) is the most common chromosomal abnormality found in Burkitt's lymphoma, resulting in the juxtaposition of the MYC gene with the immunoglobulin heavy chain gene enhancer. This leads to the overexpression of MYC, contributing to unchecked cell proliferation and tumor formation.
**Why Each Wrong Option is Incorrect**
**Option A:** Not a correct association, as Burkitt's lymphoma is not primarily associated with T cells.
**Option B:** While follicular lymphoma is a type of B-cell lymphoma, it is not the primary cell type associated with Burkitt's lymphoma.
**Option C:** Mantle cell lymphoma is another type of B-cell lymphoma, but it is characterized by a different chromosomal translocation and clinical presentation.
**Clinical Pearl / High-Yield Fact**
Burkitt's lymphoma is known for its rapid growth and high sensitivity to chemotherapy, particularly with regimens containing cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP).
**Correct Answer: C. B cells.**