## **Core Concept**
Burkitt's lymphoma is a type of non-Hodgkin lymphoma (NHL) that originates from B cells. It is characterized by a high level of malignancy and is known for its rapid growth rate. The disease is associated with a specific chromosomal translocation involving the MYC gene.

## **Why the Correct Answer is Right**
The correct answer, B cells, is right because Burkitt's lymphoma is a B-cell malignancy. This type of lymphoma arises from mature B cells that have undergone a specific genetic mutation, typically the t(8;14) translocation, which leads to overexpression of the MYC oncogene. This translocation involves the immunoglobulin heavy chain gene on chromosome 14 and the MYC gene on chromosome 8, disrupting normal cell cycle regulation and leading to uncontrolled cell proliferation.

## **Why Each Wrong Option is Incorrect**
- **Option A:** T cells are incorrect because Burkitt's lymphoma is not derived from T cells but from B cells. T-cell lymphomas are a different category of lymphoid malignancies.
- **Option C:** Plasma cells are incorrect because, although plasma cells are mature B cells, Burkitt's lymphoma is specifically known to arise from B cells before they differentiate into plasma cells.
- **Option D:** Natural Killer (NK) cells are incorrect because Burkitt's lymphoma is not associated with NK cells, which are involved in a different type of immune response and are associated with other types of lymphomas.

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that Burkitt's lymphoma is highly aggressive and requires intensive chemotherapy for treatment. It is also notable for its association with Epstein-Barr virus (EBV), particularly in endemic cases. The disease presents rapidly with symptoms such as abdominal mass, bone marrow involvement, and CNS symptoms.

## **Correct Answer:** . B cells