BRCA1 gene is located on?
Correct Answer: Chromosome 17
Description: BRCA1 gene is located on the chromosome 17. Mutations in the BRCA1, BRCA2, account for 80% of cases of familial breast cancer. In addition to breast cancer, women with BRCA1 mutation have a substantially higher risk of epithelial ovarian cancers & men have a slightly higher risk of prostate cancer. Likewise mutation in the BRCA2 gene increase the risk of breast cancer in both men & women as well as cancer of the ovary, prostate, pancreas, bile ducts, stomach & melanocytes. Ref: Robbins Basic Pathology ed 8 pg 205.
Category:
Pathology
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