BRCA 2 gene is associated with carcinoma of
**Core Concept**
The BRCA2 gene is a tumor suppressor gene that plays a crucial role in maintaining genome stability by repairing DNA double-strand breaks through homologous recombination. Mutations in the BRCA2 gene can lead to an increased risk of developing certain types of cancer.
**Why the Correct Answer is Right**
The BRCA2 gene is associated with an increased risk of breast and ovarian cancer in women, as well as prostate cancer in men. This is because the BRCA2 gene helps to repair DNA damage that can occur in these tissues. When the BRCA2 gene is mutated, the DNA repair process is impaired, leading to an accumulation of genetic mutations that can contribute to cancer development. Specifically, BRCA2 mutations are associated with an increased risk of breast cancer in women, particularly those of Ashkenazi Jewish descent.
**Why Each Wrong Option is Incorrect**
**Option A:** While BRCA1 is another gene associated with breast cancer, BRCA2 is not typically associated with carcinoma of the cervix.
**Option B:** BRCA2 is not directly associated with carcinoma of the colon.
**Option C:** Although BRCA2 mutations can increase the risk of certain cancers, they are not typically associated with carcinoma of the lung.
**Clinical Pearl / High-Yield Fact**
The BRCA2 gene is one of the most well-studied tumor suppressor genes, and mutations in this gene are associated with an increased risk of developing breast, ovarian, and prostate cancer. Women with a family history of breast or ovarian cancer should be screened for BRCA2 mutations, especially those of Ashkenazi Jewish descent.
**Correct Answer:** C.