BRCA 1 positive woman have____ % increased risk of breast carcinoma

**Question:** BRCA 1 positive woman have what % increased risk of breast carcinoma?

**Core Concept:** BRCA1 and BRCA2 are tumor suppressor genes that play a role in maintaining genomic stability by repairing damaged DNA. Mutations in these genes increase the risk of developing breast and ovarian cancer. BRCA1 mutations are associated with a higher risk than BRCA2 mutations.

**Why the Correct Answer is Right:** A woman with a BRCA1 mutation has a significantly increased risk of developing breast carcinoma. The increased risk can vary depending on the specific mutation and other factors, but in general, the risk is higher than that of the general population. In this case, the correct answer is **C.**

**Why Each Wrong Option is Incorrect:**

A. This answer is incorrect because it does not represent the increased risk associated with a BRCA1 mutation.
B. Although the risk of ovarian cancer increases in BRCA1 carriers, the primary focus of this question is on breast carcinoma risk, and the correct answer addresses that aspect.
D. This answer does not accurately reflect the risk associated with a BRCA1 mutation.

**Clinical Pearl / High-Yield Fact:** Understanding genetic mutations like BRCA1 and their implications in cancer risk is crucial for healthcare professionals to provide appropriate counseling and preventive measures for patients and their families.

**Correct Answer:** C. BRCA1 positive woman have a 50-70% increased risk of breast carcinoma.