**Core Concept:** BRCA-1 is a tumor suppressor gene located on specific chromosomes that plays a crucial role in DNA repair and cell cycle regulation. Mutations in this gene increase the risk of developing breast, ovarian, and other cancers.

**Why the Correct Answer is Right:** The BRCA-1 gene is located on chromosome 17. It is a tumor suppressor gene that helps maintain genomic stability by participating in DNA repair and cell cycle regulation. Mutations in this gene can lead to the development of breast, ovarian, and other cancers due to the loss of its protective functions.

**Why Each Wrong Option is Incorrect:**
A. **Option A:** Chromosome 13 is incorrect because the BRCA-1 gene is located on chromosome 17, not 13.
B. **Option B:** Chromosome 16 is incorrect as the gene is not present on this chromosome.
C. **Option C:** Chromosome 2 is incorrect since the BRCA-1 gene is located on chromosome 17, not chromosome 2.
D. **Option D:** Chromosome 15 is incorrect as the gene is not present on this chromosome.

**Clinical Pearl / High-Yield Fact:** Understanding the location of genes and their functions is essential for understanding genetic disorders, drug targets, and therapeutic interventions. Knowledge of gene location helps in interpreting genetic test results and making informed clinical decisions.