**Core Concept:**
The BRCA-1 gene is a key player in DNA damage repair and is particularly significant in breast and ovarian cancer susceptibility. It is one of two genes, along with BRCA-2, that account for a significant proportion of hereditary breast and ovarian cancer cases. BRCA stands for "BReast CAncer" and the "1" refers to the original discovery of the gene in 1994.

**Why the Correct Answer is Right:**
The BRCA-1 gene is located on Chromosome 17. Specifically, it is located on Chromosome 17p13. The correct answer is "C." This is because Chromosome 17 is known to harbor several important genes, including BRCA-1.

**Why Each Wrong Option is Incorrect:**
A. Chromosome 13 (Option A) and Chromosome 12 (Option D) are incorrect because they do not contain the BRCA-1 gene.
B. Although Chromosome 14 (Option B) is a chromosome, the BRCA-1 gene is not present on this chromosome, making Option B incorrect.

**Clinical Pearl / High-Yield Fact:**
Understanding the location of the BRCA-1 gene is crucial for clinical practice, as genetic testing for BRCA mutations is often conducted to assess an individual's risk for developing breast and ovarian cancer. Knowledge of the gene's location helps in interpreting the test results and offering appropriate counseling and management options to patients.

**Correct Answer:** . 17p13