Botulinum toxin blocks neuromuscular transmission by which of the following mechanism:

A. Closure of Ca++ channels at presynaptic membrane

B. Closure of Na+ channels at the postsynaptic membrane

C. Opening of K+channels at the presynaptic membrane

D. Opening of Cl– channels at the postsynaptic membrane

Correct Answer: Closure of Ca++ channels at presynaptic membrane

Description: Botulinum toxin acts by inhibiting the calcium mediated exocytosis of ACh from the vesicles in the synapse.

Category: Pharmacology

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