Botulinum toxin blocks neuromuscular transmission by the following mechanism:

A. Closure of Ca++ channels at presynaptic membrane

B. Closure of Na+ channels at the postsynaptic membrane

C. Opening of K+ channels at the presynaptic membrane

D. Opening of Cl- channels at the postsynaptic membrane

Correct Answer: Closure of Ca++ channels at presynaptic membrane

Description: Ref:KD Tripathi pharmacology 7th edition (page.no: 99) Botulinum toxins A and B are highly potent exotoxins produced by Clostridium botulinum that is responsible for Botulism. These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with axonal protein involved in exocytic release of Ach and thereby closing the calcium channel in the pre synaptic membrane

Category: Pharmacology

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