Pharmacology Both loop diuretics and thiazides can cause hypokalemia by: A Inhibiting proximal tubular K+reabsorption B Inhibiting Na+-K+-2Cl-cotranspo in the ascending limb of loop of Henle C Increasing the availability of Na+in the distal tubular fluid to exchange with interstitial K+ D Potentiating the action of aldosterone 💡 Explanation Both loop diuretics and thiazides can cause hypokalemia by: ✓ Correct Answer: C. Increasing the availability of Na+in the distal tubular fluid to exchange with interstitial K+