**Core Concept**
ITP, or Immune Thrombocytopenic Purpura, is an autoimmune disorder characterized by the production of antibodies against platelets, leading to their premature destruction in the spleen. This results in thrombocytopenia, which is a low platelet count.
**Why the Correct Answer is Right**
The typical bone marrow finding in ITP is an increase in megakaryocytes, which are the bone marrow cells responsible for producing platelets. This is because the body attempts to compensate for the peripheral destruction of platelets by increasing platelet production in the bone marrow. The increase in megakaryocytes is a hallmark of ITP on bone marrow examination.
**Why Each Wrong Option is Incorrect**
**Option A:** This option would be incorrect because a decrease in megakaryocytes would be more indicative of a platelet production disorder, such as thrombocytopenia due to bone marrow failure.
**Option B:** This option would be incorrect because a normal or decreased number of megakaryocytes would be more indicative of a non-hematological disorder, such as liver disease or malnutrition.
**Option C:** This option would be incorrect because an increase in erythrocyte precursors would be more indicative of a disorder of red blood cell production, such as anemia of chronic disease.
**Clinical Pearl / High-Yield Fact**
In ITP, the bone marrow typically shows an increase in megakaryocytes, which is a compensatory response to peripheral platelet destruction. This finding is essential in distinguishing ITP from other causes of thrombocytopenia.
**Correct Answer:** A. Increase in megakaryocytes.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.