Bone marrow depression is seen with chronic administration of –
**Core Concept**
Bone marrow depression, also known as myelosuppression, refers to the decrease in the production of blood cells due to bone marrow dysfunction. This can be caused by various factors, including medications. **Myelotoxicity** is a common side effect of certain drugs, leading to a reduction in blood cell counts.
**Why the Correct Answer is Right**
Chronic administration of certain drugs can lead to bone marrow depression by interfering with the proliferation and maturation of blood cell precursors. This can result in **anemia**, **leukopenia**, and **thrombocytopenia**.
**Why Each Wrong Option is Incorrect**
**Option A:** Not enough information to determine its correctness.
**Option B:** Not enough information to determine its correctness.
**Option C:** Not enough information to determine its correctness.
**Clinical Pearl / High-Yield Fact**
It is essential to monitor blood cell counts in patients receiving chronic medication to detect myelosuppression early.
**Correct Answer:** D. Chloramphenicol.