**Core Concept**
Dohle bodies are azurophilic granules found in the cytoplasm of neutrophils, typically seen in conditions associated with acute infection, inflammation, or stress.
**Why the Correct Answer is Right**
Dohle bodies are formed due to the aggregation of ribosomal RNA and proteins within the neutrophil cytoplasm. They are a sign of cellular stress and are often seen in conditions like sepsis, acute leukemia, or following severe burns. The presence of Dohle bodies can be identified using a Wright's stain or a Giemsa stain.
**Why Each Wrong Option is Incorrect**
**Option A:** Dohle bodies are not typically seen in conditions like viral infections or autoimmune diseases, which often present with different types of cellular inclusions.
**Option B:** While Dohle bodies can be found in some cases of acute leukemia, they are not a specific diagnostic criterion for this condition.
**Option C:** Dohle bodies are not a characteristic finding in conditions like tuberculosis or chronic infections, which often present with different types of cellular responses.
**Clinical Pearl / High-Yield Fact**
Dohle bodies are often seen in conditions where there is a significant release of inflammatory cytokines and a subsequent increase in neutrophil turnover. This can be a useful diagnostic clue in differentiating between various types of infections and inflammatory conditions.
**Correct Answer:** C. Leukemia.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.