A 42-year-old man requires transfusion for blood loss resulting from an automobile accident. During the infusion, he develops urticaria, stridor, and hypotension requiring IV epinephrine. Further history reveals frequent episodes of sinusitis and bronchitis. Select the one most likely immunologic deficiency

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Vikas Bhardwaj
Medical Technologist, AIIMS New Delhi
Updated: Apr 17, 2026