**Core Concept**
The breakdown of glycogen to glucose is a crucial step in maintaining blood glucose levels, particularly during fasting periods. Glycogen, a complex carbohydrate stored in the liver and muscles, is hydrolyzed to glucose-6-phosphate by the enzyme glycogen phosphorylase. However, for glucose-6-phosphate to be released into the bloodstream, it must be converted into glucose.

**Why the Correct Answer is Right**
Glycogen in the liver can contribute directly to blood glucose through the process of glycogenolysis. The enzyme glucose-6-phosphatase, present in the liver, catalyzes the conversion of glucose-6-phosphate to glucose, which is then released into the bloodstream. In contrast, muscle glycogen is primarily used to meet the energy demands of the muscle itself, and glucose-6-phosphatase is not present in muscle tissue. As a result, muscle glycogen is incapable of contributing directly to blood glucose.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify a tissue where glycogen cannot contribute to blood glucose.
* **Option B:** This option is incorrect because it is a distractor and does not directly relate to the question.
* **Option D:** This option is incorrect because it is a distractor and does not directly relate to the question.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the liver is the primary site of glycogenolysis and gluconeogenesis, playing a critical role in maintaining blood glucose levels during fasting. The presence of glucose-6-phosphatase in the liver allows it to release glucose into the bloodstream, whereas muscle glycogen is primarily used for local energy production.

**Correct Answer:** C. Muscle