Raised aPTT is seen in all of the following bleeding disorder except: March 2009
**Core Concept**
The activated partial thromboplastin time (aPTT) assesses the intrinsic and common coagulation pathways, involving factors VIII, IX, XI, and XII. A prolonged aPTT indicates a defect in one or more of these pathways, leading to an increased risk of bleeding.
**Why the Correct Answer is Right**
A raised aPTT is characteristic of bleeding disorders such as hemophilia A (deficiency of factor VIII), hemophilia B (deficiency of factor IX), and von Willebrand disease (deficiency of von Willebrand factor, which binds and stabilizes factor VIII). In these conditions, the aPTT is prolonged due to the impaired function of the respective factors. This is because the aPTT measures the time it takes for blood to clot in the presence of tissue factor, which activates the intrinsic pathway.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because a normal or slightly elevated aPTT is seen in thrombotic thrombocytopenic purpura (TTP), a disorder characterized by the formation of blood clots in small blood vessels throughout the body. In TTP, the aPTT is not raised due to a bleeding disorder, but rather due to the consumption of clotting factors and platelets.
**Option B:** This option is incorrect because a prolonged aPTT can be seen in liver disease, which affects the production of multiple clotting factors. In liver disease, the aPTT is often prolonged due to the impaired synthesis of clotting factors, such as factor VII, IX, X, and fibrinogen.
**Option C:** This option is incorrect because a prolonged aPTT can be seen in the use of heparin, an anticoagulant that inhibits the coagulation cascade. In heparin therapy, the aPTT is often prolonged due to the inhibition of factor Xa and thrombin.
**Option D:** This option is incorrect because a prolonged aPTT can be seen in factor XI deficiency, a bleeding disorder that affects the intrinsic pathway.
**Clinical Pearl / High-Yield Fact**
It is essential to note that a prolonged aPTT can be caused by a variety of factors, including bleeding disorders, liver disease, and heparin therapy. Therefore, a prolonged aPTT should be evaluated in the context of the patient's clinical presentation and laboratory results.
**Correct Answer: A. Thrombotic thrombocytopenic purpura (TTP)**