**Core Concept**
The intestinal biopsy specimen of a patient with celiac disease or gluten-sensitive enteropathy shows villous atrophy and crypt hyperplasia due to immune-mediated damage to the small intestinal mucosa triggered by ingestion of gluten.
**Why the Correct Answer is Right**
The condition shown in the intestinal biopsy specimen before diet restriction is characterized by villous atrophy, which is a hallmark of celiac disease. This is due to the immune response to gluten, leading to inflammation and damage to the small intestinal mucosa. The enzyme tissue transglutaminase (TTG) plays a crucial role in the pathogenesis of celiac disease by modifying gluten peptides, making them more immunogenic.
**Why Each Wrong Option is Incorrect**
**Option A:** The presence of crypt hyperplasia is a true feature of the condition shown, as it is a compensatory response to villous atrophy.
**Option B:** The condition shown is indeed associated with malabsorption, which is a common clinical manifestation of celiac disease.
**Option C:** The intestinal biopsy specimen before diet restriction shows significant inflammation and immune activation, which is a characteristic feature of the condition.
**Clinical Pearl / High-Yield Fact**
Celiac disease is a classic example of an autoimmune disorder triggered by dietary factors, emphasizing the importance of a thorough dietary history in the diagnosis of gastrointestinal disorders.
**Correct Answer: A.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.