**Core Concept**
Randomization is a crucial method to minimize bias in clinical trials. It involves assigning participants to different treatment groups in a way that is random and unpredictable, thereby reducing the influence of confounding variables and ensuring that each group is comparable to the others.

**Why the Correct Answer is Right**
Randomization is an essential component of good clinical trial design, as it helps to eliminate selection bias, where participants are inadvertently assigned to treatment groups due to their characteristics or circumstances. By using randomization, researchers can ensure that the groups are comparable in terms of demographic and clinical characteristics, reducing the risk of bias and allowing for more accurate comparisons between treatment groups. Randomization can be done using various methods, such as simple randomization, stratified randomization, or blocked randomization.

**Why Each Wrong Option is Incorrect**
**Option A:** **Matching** is a method used to reduce bias by pairing participants with similar characteristics, but it does not eliminate bias altogether, as it may not account for all potential confounding variables.
**Option B:** **Regression analysis** is a statistical method used to control for confounding variables, but it is not a method to eliminate bias in the design of clinical trials.
**Option C:** **Blinding** is a method used to reduce bias by preventing participants or researchers from knowing which treatment is being administered, but it does not eliminate bias in the assignment of participants to treatment groups.

**Clinical Pearl / High-Yield Fact**
When designing a clinical trial, always use a randomization method that is unpredictable and unbiased, such as a computer-generated randomization list, to minimize the risk of selection bias.

**Correct Answer:** D. Blinding