**Core Concept**
Lipid-insoluble beta blockers, also known as hydrophilic beta blockers, are a class of beta blockers that do not readily cross the lipid bilayer of cell membranes due to their water-soluble properties. This characteristic affects their pharmacokinetic and pharmacodynamic profiles.

**Why the Correct Answer is Right**
Lipid-insoluble beta blockers, such as atenolol and nadolol, do not have a significant membrane stabilizing effect. This is because their water-soluble properties prevent them from interacting with the lipid bilayer of cell membranes, which is a critical step in the development of membrane stabilizing effects. Membrane stabilizing effects are more pronounced in lipid-soluble beta blockers, such as propranolol, which readily cross the lipid bilayer and interact with sodium channels.

**Why Each Wrong Option is Incorrect**
**Option A:** Lipid-insoluble beta blockers do not cross the blood-brain barrier due to their water-soluble properties, making this statement true.
**Option C:** Lipid-insoluble beta blockers, such as atenolol, are highly absorbed orally, making this statement false.
**Option D:** Lipid-insoluble beta blockers, such as nadolol, are long-acting due to their extensive hepatic metabolism and long elimination half-life, making this statement true.

**Clinical Pearl / High-Yield Fact**
When choosing a beta blocker, it's essential to consider the patient's specific needs and comorbidities. Lipid-insoluble beta blockers may be preferred in patients with asthma or chronic obstructive pulmonary disease (COPD) due to their reduced bronchoconstrictive effects.

**✓ Correct Answer: B. Have good membrane stabilizing effect**