Benzodiazepine acts through:
Correct Answer: GABAA
Description: Ans: a (GABA A) Ref: KDT, 6 ed, p. 394The benzodiazepine receptor modulates GABA A receptor in either direction. Agonists like diazepam facilitate, while inverse agonists like DMCM hinder GABA A mediated Cl- channel opening and benzodiazepine antagonist like flumazenil block the action of both.GABAA BZD Receptor--Cl Channel complexDrugs acting on GABA receptor gated chloride channel:Muscimol: GABAa agonistBicuculline: GABAa competitive antagonistBarbiturate : agonist at allosteric site (?picrotoxin site) - prolong GABA action ie, open cl- channel.Picrotoxin: blocks cl- channel competitivelyBenzodiazepine: agonist at allosteric BZD site- facilitate GABA actionsscarboline (DMCM): inverse agonist at BZD site- impede GABA action.Flumazenil: competitive antagonist at BZD site.Remember:GABAB: G protein coupled receptor. Hyperpolarizes neurons by increasing K+conductance.Baclofen GABAB agonistSaclofen: GABAB receptor blocker
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now