Basophilic inclusion bodies are seen in –
**Core Concept**
Basophilic inclusion bodies are characteristic pathological features seen in certain viral infections, where viral proteins accumulate within the host cells, disrupting their normal function. These inclusions are typically found in the cytoplasm of infected cells and can be stained with basic dyes like hematoxylin, giving them a characteristic blue color.
**Why the Correct Answer is Right**
The correct answer is related to the viral infection that causes the formation of basophilic inclusion bodies. These inclusions are formed due to the accumulation of viral proteins, such as the viral core or capsid, within the host cell. This process disrupts the normal cellular function and can lead to cell death. The specific virus that is associated with basophilic inclusion bodies is the *Cytomegalovirus (CMV)*.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify a virus that is known to cause basophilic inclusion bodies. While some viruses may cause similar inclusions, they are not the primary example.
* **Option B:** This option is incorrect because it is a type of bacterial infection, not a viral infection, and does not cause basophilic inclusion bodies.
* **Option C:** This option is incorrect because it is a type of fungal infection, not a viral infection, and does not cause basophilic inclusion bodies.
**Clinical Pearl / High-Yield Fact**
One important clinical correlation to remember is that basophilic inclusion bodies are often seen in the context of viral infections, particularly in the setting of immunocompromised patients. Therefore, if you see basophilic inclusion bodies on a histopathology slide, consider the possibility of a viral infection, especially in patients with weakened immune systems.
**Correct Answer: D. Cytomegalovirus (CMV)**