Decrease in the normal basophilia of the nuclear chromatin in a necrotic cell is known as:
**Core Concept**
The basophilia of the nuclear chromatin, also known as Feulgen staining, is a measure of the amount of DNA present in a cell. In necrotic cells, the normal basophilia of the nuclear chromatin is decreased due to DNA degradation.
**Why the Correct Answer is Right**
The decrease in basophilia in necrotic cells is due to the breakdown of DNA, which results in the loss of negatively charged phosphate groups. This leads to a decrease in the affinity of the DNA for basic dyes, such as Feulgen stain, resulting in a decrease in basophilia. The cell's chromatin is composed of tightly coiled DNA and histone proteins, and the degradation of DNA results in the loss of the negatively charged phosphate groups, leading to a decrease in basophilia.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not relevant to the decrease in basophilia in necrotic cells.
**Option B:** This option is not a term used to describe the decrease in basophilia in necrotic cells.
**Option C:** This option is not a characteristic of necrotic cells.
**Clinical Pearl / High-Yield Fact**
The Feulgen stain is a type of basic dye that is used to stain DNA, and the decrease in basophilia in necrotic cells is a useful indicator of cell death.
**Correct Answer:** . Karyolysis.