All of the following is true about basal cell carcinoma except
**Core Concept**
Basal cell carcinoma (BCC) is the most common type of skin cancer, accounting for approximately 80% of all skin cancer cases. It arises from the basal cell layer of the epidermis and is characterized by uncontrolled growth of abnormal cells. BCC is typically slow-growing and locally invasive.
**Why the Correct Answer is Right**
BCC is indeed the most common type of skin cancer, and it arises from the basal cell layer of the epidermis. It is characterized by uncontrolled growth of abnormal cells, which are typically slow-growing and locally invasive. The growth of BCC is driven by mutations in the PTCH1 gene, which leads to the activation of the sonic hedgehog (SHH) signaling pathway. This pathway promotes the proliferation of basal cell cells and inhibits their apoptosis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because BCC can indeed metastasize, although it is extremely rare (less than 0.1% of cases). However, it is worth noting that BCC is generally considered to be non-metastatic.
**Option B:** This option is incorrect because BCC is not typically associated with a high risk of lymph node metastasis. However, it is worth noting that BCC can cause local destruction and erosion of surrounding tissues.
**Option C:** This option is incorrect because BCC is not typically associated with a high risk of distant metastasis. However, it is worth noting that BCC can cause local destruction and erosion of surrounding tissues.
**Option D:** This option is incorrect because BCC is not typically associated with a high risk of distant metastasis. However, it is worth noting that BCC can cause local destruction and erosion of surrounding tissues.
**Clinical Pearl / High-Yield Fact**
BCC is typically slow-growing, but it can cause significant local destruction and erosion of surrounding tissues. It is worth noting that BCC is often associated with exposure to ultraviolet (UV) radiation, particularly in individuals with fair skin.
**Correct Answer:**
B.