Barr body is absent in –
**Core Concept**
Turner syndrome, a genetic disorder in females, is characterized by the presence of an abnormal karyotype, typically 45,X. The absence of a Barr body in these individuals is a direct consequence of the monosomy X.
**Why the Correct Answer is Right**
In normal females with a 46,XX karyotype, one of the two X chromosomes is inactivated to form a Barr body. This inactivation occurs through the process of X-chromosome inactivation (XCI), which ensures dosage compensation for genes present on the X chromosome. In Turner syndrome, the individual has only one X chromosome, which means there is no second X chromosome to inactivate, resulting in the absence of a Barr body. This is a key diagnostic feature of Turner syndrome.
**Why Each Wrong Option is Incorrect**
**Option A:** Kleinfelter syndrome is characterized by the presence of an extra X chromosome (47,XXY), which would lead to the presence of multiple Barr bodies, not their absence.
**Option C:** Super female refers to individuals with a 47,XXX karyotype, who would have multiple X chromosomes and thus multiple Barr bodies, not none.
**Option D:** This option is incorrect because Turner syndrome is a specific condition where the Barr body is indeed absent.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that the absence of a Barr body is a diagnostic feature of Turner syndrome, and its presence or absence can be used to differentiate this condition from other sex chromosome abnormalities.
**β Correct Answer: B. Turner**