**Core Concept**
Acute barbiturate poisoning is a medical emergency requiring prompt treatment to prevent severe complications, including respiratory depression, cardiac arrest, and seizures. The goal of treatment is to enhance elimination of the toxin, manage symptoms, and support vital organ function.

**Why the Correct Answer is Right**
Activated charcoal is administered orally to prevent further absorption of the barbiturate from the gastrointestinal tract. This is particularly effective when given within one hour of ingestion. Gastric lavage may also be considered in selected cases, but its use is limited by the risk of aspiration and the need for rapid administration. Flumazenil, a benzodiazepine antagonist, is not effective in reversing barbiturate-induced sedation.

**Why Each Wrong Option is Incorrect**
**Option A:** Supportive care alone is insufficient for managing acute barbiturate poisoning, as it does not address the ongoing absorption of the toxin.
**Option B:** Hemodialysis is not typically effective for barbiturate elimination, as these compounds have large volumes of distribution and are extensively protein-bound.
**Option C:** Naloxone, an opioid antagonist, has no role in the treatment of barbiturate poisoning.

**Clinical Pearl / High-Yield Fact**
Activated charcoal is most effective when administered within one hour of ingestion to prevent further absorption of the toxin.

**Correct Answer: C. Naloxone has no role in the treatment of barbiturate poisoning.**