B6. Following is not true about the gene mutations leading to breast carcinoma

A. Most common mutation in inherited breast carcinoma is BRCA1

B. BRCA 1 mutation is present in most of the cases of breast carcinoma

C. Inherited breast carcinomas make about 3 % of the total cases

D. p53 mutation also increases chances of colon and brain cancer

Correct Answer: BRCA 1 mutation is present in most of the cases of breast carcinoma

Description: Ans. (b) BRCA 1 mutation is present in most of the cases of breast carcinoma(Ref: Robbins 9th/pg 1054; 8th/pg 1077)a. Most common gene involved in familial breast cancer-BRCA1(52%) > BRCA1(32%)b. p53 mutation is present in most of the cases of breast carcinomac. Inherited breast carcinomas make about 3 % of the total casesd. p53 mutation increases risk of all cancers

Category: Pathology

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