CLL usually pursues an indolent course, but B-cell prolymphocytic leukemia which is a subtype behave more aggressively. B-cell prolymphocytic leukemia (B-PLL) is a rare disease, characterized by splenomegaly, no lymphadenopathy, marked lymphocytosis with prolymphocytes exceeding 55% of circulating lymphoid cells, poor response to therapy and sho survival. Among the options provided 'Having a shoer interval' is the single best answer of choice. Ref: Principles and Practice of Internal Medicine, 16th Edition, Pages 648, 649, 652; CMDT By Stephen J. McPhee, Maxine A.Papadakis, 2009, Page 454-55.