Following is transmitted as autosomal dominant disorder –
**Core Concept**
Autosomal dominant disorders are characterized by a mutation in one of the two copies of a gene, leading to the expression of the disease phenotype. This means that only one copy of the mutated gene is required for the individual to exhibit the disorder. Autosomal dominant disorders have a 50% chance of being passed on to each offspring.
**Why the Correct Answer is Right**
The correct option is a classic example of an autosomal dominant disorder. It is a genetic disorder caused by a mutation in a specific gene that codes for a protein involved in cell growth and division. The mutated gene leads to excessive cell growth, resulting in the characteristic features of the disorder. The presence of a single copy of the mutated gene is sufficient to cause the disease, making it an autosomal dominant disorder.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it is a recessive disorder, requiring two copies of the mutated gene (one from each parent) to express the disease phenotype.
* **Option B:** This option is incorrect because it is a multifactorial disorder, influenced by both genetic and environmental factors, and does not follow a simple autosomal dominant pattern of inheritance.
* **Option C:** This option is incorrect because it is a sex-linked disorder, affecting only one of the two copies of the gene (X or Y chromosome), and is not transmitted as an autosomal dominant disorder.
**Clinical Pearl / High-Yield Fact**
Autosomal dominant disorders often have a high penetrance, meaning that individuals with the mutated gene are more likely to express the disease phenotype. This is in contrast to autosomal recessive disorders, which require two copies of the mutated gene to express the disease.
**Correct Answer: C.**