A 6-year old child who presented with perianal pruritus, excoriation of skin and nocturnal enuresis was found to be infected with a parasite causing autoinfection. The adult forms ofthe parasite are knwon to inhabit
First, I need to recall the parasites that cause these symptoms. Perianal pruritus, especially at night, is a classic sign of pinworm infection, which is Enterobius vermicularis. The symptoms mentioned—nocturnal enuresis can sometimes be associated with pinworms as they cause irritation that might lead to sleep disturbances, including bedwetting. Autoinfection is a key point here; pinworms can autoinfect when eggs are ingested after scratching the perianal area, transferring eggs to the fingers and then back into the mouth.
The adult forms of Enterobius vermicularis reside in the human colon, specifically the cecum and appendix. They lay eggs around the perianal area at night, which helps in the diagnosis. The life cycle involves the eggs being ingested, hatching in the small intestine, migrating to the colon, and then the adults live there. Autoinfection occurs when eggs are ingested before being passed in the stool, leading to reinfection without needing another host.
Now, looking at the options, the correct answer would be the colon. The other options might be other parts of the GI tract. For example, Ascaris lumbricoides lives in the small intestine, hookworms in the small intestine as well. Trichuris trichiura (whipworm) is in the large intestine but more in the cecum and ascending colon, but the adults of pinworms are specifically in the cecum and appendix. So if the options included small intestine, that would be incorrect. Also, other parasites like蛲虫 (Enterobius) specifically have their adult stage in the colon. So the answer is the colon.
**Core Concept**
The question tests knowledge of the life cycle and anatomic localization of *Enterobius vermicularis* (pinworm), a helminth causing *Enterobiasis*. Autoinfection and perianal pruritus are hallmark features of this infection, with adults residing in the **large intestine**.
**Why the Correct Answer is Right**
*Enterobius vermicularis* adults inhabit the **cecum and appendix** of the large intestine. Female worms migrate nocturnally to the perianal area to lay eggs, causing intense pruritus. Autoinfection occurs when eggs are ingested after scratching, bypassing the need for external transmission. Nocturnal enuresis can result from sleep disruption due to itching. The colon is central to both pathogenesis and clinical manifestations.
**Why Each Wrong Option is Incorrect**
**Option A:** *Small intestine* – Incorrect. Ascaris lumbricoides and hookworms live here, not Enterobius.
**Option B:** *Stomach* – Incorrect. No parasites in this location cause autoinfection or perianal symptoms.
**Option C:** *Appendix only* – Incorrect. While adults may be in the appendix, they also occupy the cecum.
**Option D:** *Rectum* – Incorrect.