All of the following autoimmune disorder are more common in females except
**Core Concept**
The question is testing the understanding of the gender predisposition of various autoimmune disorders. Autoimmune disorders occur when the immune system mistakenly attacks and damages the body's own cells, tissues, and organs. The gender predisposition of autoimmune disorders is influenced by various factors, including hormonal, genetic, and environmental factors.
**Why the Correct Answer is Right**
Autoimmune disorders such as Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and Hashimoto's Thyroiditis are more common in females due to the influence of estrogen on the immune system. Estrogen can enhance the activity of immune cells and increase the production of autoantibodies. Additionally, females are more likely to have a family history of autoimmune disorders, which can also contribute to their increased risk.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Sjögren's Syndrome, an autoimmune disorder characterized by dry eyes and dry mouth, is more common in females.
**Option B:** This option is incorrect because Multiple Sclerosis (MS), an autoimmune disorder affecting the central nervous system, is also more common in females.
**Option C:** This option is incorrect because Guillain-Barré Syndrome, an autoimmune disorder characterized by muscle weakness and paralysis, is more common in males.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that while females are more likely to develop autoimmune disorders, males are more likely to develop severe and life-threatening forms of these disorders.
**Correct Answer: C. Guillain-Barré Syndrome. Guillain-Barré Syndrome is more common in males.**