**Core Concept:** The question is testing the understanding of sexually transmitted infections (STIs) and their attributable risks in a population. It specifically focuses on the increased risk of cervical cancer (CaCx) due to multiple sexual partners.
**Why the Correct Answer is Right:** In populations with high rates of sexually transmitted infections (STIs), the risk of developing CaCx can be increased due to the presence of high-risk human papillomavirus (HPV), which is the primary cause of CaCx. Multiple sexual partners expose an individual to a greater number of high-risk HPV types, resulting in a higher risk of developing CaCx. The attributable risk refers to the proportion of cases that can be attributed to a specific risk factor in a population. In this case, having multiple sexual partners leads to a 5-fold increased risk of CaCx.
**Why Each Wrong Option is Incorrect:**
A. HPV infection is a significant risk factor for CaCx development, but the increased risk is due to the presence of multiple sexual partners, not just the infection itself.
B. While HPV is a primary cause of CaCx, the increased risk is not solely due to the infection but rather the increased exposure to multiple sexual partners.
C. HPV infection and multiple sexual partners both contribute to the increased risk, but the question specifically asks for the attributable risk due to multiple sexual partners.
D. HPV infection is a significant risk factor for CaCx, but the increased risk is due to the combination of HPV and multiple sexual partners, not just HPV infection alone.
**Clinical Pearl:** In clinical practice, understanding the attributable risks of various risk factors is crucial for providing appropriate counseling to patients about preventive measures and screening guidelines. It highlights the importance of practicing safe sex and limiting sexual partners as a means to reduce the risk of HPV transmission and subsequent CaCx development.
Free Medical MCQs · NEET PG · USMLE · AIIMS
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