Atracurium is metabolized by –
Correct Answer: Hoffman degradation
Description: Ans. B. Hoffman degradationThe unique feature of atracurium is inactivation in plasma by spontaneous non enzymatic degradation (Hofmann elimination).Consequently its duration of action is not altered in patients with hepatic/renal insufficiency or hyperdynamic circulation ---> Hence, preferred muscle relaxant for such patients as well as for neonates and the elderly.Atracuum is metabolised to laudanosine that is responsible for seizures.Cause histamine release > Hypotension, bronchoconstriction & flushing.
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