Atracurium is excreted by –
Correct Answer: Nonenzymatic degradation
Description: Ans. is 'c' i.e., Nonenzymatic degradation o The unique feature of atracurium is inactivation in plasma by spontaneous nonenzymatic degradation (Hofmann elimination) in addition to that by alkaline ester hydrolysis.o Consequently, its duration of action is not altered in patients with hepatic/renal insufficiency or hyperdynamic circulation - Preferred muscle relaxant for such patients as well as for neonates and the elderly.o Atracurium is metabolized to laudanosine that is responsible for seizures,o It can cause histamine release Hypotension & bronchoconstriction.
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