**Core Concept**
Intestinal amoebiasis is caused by the protozoan parasite Entamoeba histolytica, which can lead to asymptomatic cyst passage, mild intestinal infection, and potentially severe invasive amoebiasis. Treatment aims to eliminate the parasite from the gut and prevent complications.
**Why the Correct Answer is Right**
The most effective drug for treating mild intestinal amoebiasis and asymptomatic cyst passers is Metronidazole. This antibiotic works by targeting the parasite's DNA, leading to the death of the amoeba. Metronidazole's effectiveness is attributed to its ability to penetrate the cysts and trophozoites of E. histolytica, thereby eradicating the parasite from the gut. The recommended treatment duration is 5-10 days.
**Why Each Wrong Option is Incorrect**
**Option A:** Paromomycin is an alternative treatment option for amoebiasis, but it is less effective than Metronomidazole in eradicating the parasite from the gut. It works by inhibiting protein synthesis in the parasite, but its efficacy is lower compared to Metronidazole.
**Option B:** Tetracycline antibiotics are not the first-line treatment for intestinal amoebiasis. They can be used in combination with Metronidazole for severe cases, but they are not as effective as Metronidazole alone.
**Option C:** Albendazole is an antiparasitic medication used to treat infections caused by worms, not protozoa like E. histolytica. It would not be effective against intestinal amoebiasis.
**Clinical Pearl / High-Yield Fact**
Remember that Metronidazole is the drug of choice for treating mild intestinal amoebiasis and asymptomatic cyst passers due to its high efficacy and ability to penetrate the parasite's cysts and trophozoites.
**Correct Answer:** A. Metronidazole
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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