Asteroid bodies are seen in histological examination in tissues infected with which of the following causative agent?
Correct Answer: Nocardiosis
Description: Asteroid bodies are seen in association with Sporotrichosis. Sporotrichosis is an infection caused by Sporothrix schenckii a thermally dimorphic fungus. In H&E stained tissue, the asteroid body consists of a central basophilic yeast cell surrounded by radiating extensions of eosinophilic material, which are depositions of antigen antibody complexes and complement. Sporotrichosis occurs following traumatic inseion of S schenckii into the skin. The initial lesion is usually located on an extremity which later develops into a granulomatous nodule that may progress to form a necrotic or ulcerative lesion. The draining lymphatics becomes thickened and cor like. It can be seen when stained with Gomori methenamine silver or periodic acid-Schiff stain. It can be cultured on Sabouraud's agar containing antibacterial antibiotics and incubated at 25-30degC. Ref:Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., Mietzner T.A. (2013). Chapter 45. Medical Mycology. In G.F. Brooks, K.C. Carroll, J.S. Butel, S.A. Morse, T.A. Mietzner (Eds), Jawetz, Melnick, & Adelberg's Medical Microbiology, 26e
Category:
Microbiology
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