A patient has history suggestive aspergillosis features(s) which would be seen includes
**Core Concept**
Aspergillosis is a fungal infection caused by Aspergillus species, which can manifest in various forms, including allergic reactions, pulmonary infections, and invasive disease. The condition often affects immunocompromised individuals, including those with chronic lung disease, cancer, or taking immunosuppressive therapy.
**Why the Correct Answer is Right**
The correct answer is associated with the pathophysiology of aspergillosis, particularly the allergic bronchopulmonary aspergillosis (ABPA) form. In ABPA, the immune system reacts to Aspergillus antigens, producing IgE antibodies and causing an allergic response. This leads to the release of histamine and other mediators, which increase mucus production, cause bronchospasm, and lead to symptoms such as coughing, wheezing, and shortness of breath.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not accurately describe a common feature of aspergillosis.
* **Option B:** This option is incorrect because, while it may be associated with some forms of aspergillosis, it is not a hallmark feature of the condition.
* **Option C:** This option is incorrect because it is not a typical manifestation of aspergillosis.
**Clinical Pearl / High-Yield Fact**
In patients with aspergillosis, particularly those with ABPA, the presence of eosinophilia (an elevated eosinophil count) and elevated IgE levels can support the diagnosis. This is a useful clinical correlation to remember when evaluating patients with respiratory symptoms.
**Correct Answer: D. Pulmonary infiltrates with eosinophilia**