**Core Concept**
Aspergillosis is a fungal infection caused by Aspergillus species, which can lead to a range of clinical manifestations depending on the host's immune status and the site of infection. It can affect various organs, including the lungs, brain, and sinuses.

**Why the Correct Answer is Right**
Aspergillosis typically presents with respiratory symptoms, such as cough, chest pain, and hemoptysis, especially in immunocompromised individuals. The infection can also cause allergic reactions, including asthma and hypersensitivity pneumonitis. In severe cases, aspergillosis can lead to invasive disease, including aspergilloma, chronic pulmonary aspergillosis, and invasive pulmonary aspergillosis. The correct answer should represent a manifestation that is not typically associated with aspergillosis.

**Why Each Wrong Option is Incorrect**
**Option A:**
Aspergillosis can indeed cause skin lesions, particularly in the context of cutaneous aspergillosis, which is a rare but serious condition that can occur in immunocompromised patients.

**Option B:**
Hepatic involvement is not a typical manifestation of aspergillosis. However, aspergillosis can cause disseminated disease, which may involve multiple organs, including the liver. But this is not a common presentation.

**Option C:**
Cardiac involvement is not a characteristic feature of aspergillosis. The infection primarily affects the lungs and, in severe cases, can disseminate to other organs, but cardiac involvement is not a typical manifestation.

**Clinical Pearl / High-Yield Fact**
Aspergillosis is more likely to occur in immunocompromised individuals, such as those with HIV/AIDS, undergoing chemotherapy, or taking corticosteroids.

**Correct Answer:** D. Cardiac involvement is not a characteristic feature of aspergillosis.