Amphotericin B (Fungizone) IV is given to a client with aspergillosis, a fungal infection. In order to prevent its side effects, the nurse anticipate administering which of the following prior, except?

**Core Concept**
The underlying principle being tested is the management of side effects associated with Amphotericin B, an antifungal medication. Amphotericin B can cause infusion-related reactions and nephrotoxicity.

**Why the Correct Answer is Right**
To mitigate these side effects, premedications such as acetaminophen, diphenhydramine, and hydrocortisone are often administered. These medications help reduce the incidence of fever, chills, and rigors associated with Amphotericin B infusion.

**Why Each Wrong Option is Incorrect**
**Option A:** Acetaminophen is given to prevent fever and chills, a common side effect of Amphotericin B.
**Option B:** Diphenhydramine is an antihistamine that can help alleviate infusion-related reactions.
**Option C:** Hydrocortisone is a corticosteroid that can reduce inflammation and prevent severe reactions.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that Amphotericin B requires careful administration and monitoring due to its potential for nephrotoxicity and infusion-related reactions.

**Correct Answer:** D.

✓ Correct Answer: B. Ketoconazole.