**Core Concept**
Panic disorder is a complex condition characterized by recurrent panic attacks, often accompanied by anticipatory anxiety and avoidance behaviors. Effective treatment involves pharmacological interventions, psychotherapy, or a combination of both to address both the symptoms and underlying psychological mechanisms.

**Why the Correct Answer is Right**
The most appropriate treatment for panic disorder involves a combination of short-term benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), and cognitive-behavioral therapy (CBT). Benzodiazepines provide rapid symptom relief by enhancing the activity of gamma-aminobutyric acid (GABA) at GABA_A receptors, thereby reducing anxiety and panic symptoms. SSRIs, such as fluoxetine or sertraline, work by increasing serotonin levels in the synaptic cleft, which helps to reduce the frequency and severity of panic attacks. CBT is a type of psychotherapy that helps individuals identify and change negative thought patterns and behaviors associated with panic disorder.

**Why Each Wrong Option is Incorrect**
**Option A:** Buspirone plus benzodiazepines is not the most appropriate treatment for panic disorder because buspirone is an anxiolytic with a slower onset of action, which may not provide sufficient relief for acute panic symptoms. Additionally, combining buspirone with benzodiazepines may increase the risk of adverse effects.
**Option B:** Benzodiazepines plus supportive therapy is not the optimal choice because benzodiazepines have a high potential for dependence and abuse, and supportive therapy alone may not address the underlying psychological mechanisms contributing to panic disorder.
**Option D:** Long-term benzodiazepine plus venlafaxine is not recommended because long-term benzodiazepine use can lead to dependence and withdrawal symptoms, and venlafaxine, an SNRI, may not be as effective as SSRIs in treating panic disorder.

**Clinical Pearl / High-Yield Fact**
The combination of short-term benzodiazepines, SSRIs, and CBT is often referred to as the "gold standard" treatment for panic disorder due to its high efficacy and safety profile. This treatment approach can help individuals achieve significant symptom reduction and improve their overall quality of life.

**✓ Correct Answer: C. Sho - term benzodiazepine plus SSRI plus CBT**