“Stary sky” appearance is seen in –
**Core Concept**
The "starry sky" appearance is a radiological term describing a pattern of multiple small, rounded or oval calcifications scattered throughout the lung parenchyma, resembling the night sky. This appearance is characteristic of lymphangitic carcinomatosis, a type of pulmonary metastasis.
**Why the Correct Answer is Right**
Lymphangitic carcinomatosis occurs when cancer cells from a primary tumor metastasize to the lung via the lymphatic system, causing obstruction and subsequent dilatation of the lymphatic vessels. As a result, the cancer cells become trapped within the expanded lymphatic spaces, forming small, rounded or oval calcifications that are visible on chest radiographs. The "starry sky" appearance is a classic radiological sign of this condition, which is often associated with adenocarcinoma of the breast or lung.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the "starry sky" appearance is not typically associated with granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis), which is characterized by a different pattern of nodular calcifications and pulmonary infiltrates.
**Option B:** This option is incorrect because the "starry sky" appearance is not a characteristic feature of pulmonary alveolar proteinosis, which typically presents with a "batwing" or "bilateral ground-glass" pattern on chest radiographs.
**Option C:** This option is incorrect because the "starry sky" appearance is not typically associated with pulmonary sarcoidosis, which often presents with bilateral hilar lymphadenopathy and pulmonary infiltrates.
**Clinical Pearl / High-Yield Fact**
The "starry sky" appearance is a classic radiological sign of lymphangitic carcinomatosis, and its presence should prompt further investigation into the possibility of metastatic disease.
**Correct Answer: D. Lymphangitic carcinomatosis**