**Core Concept**
Apoptosis is a form of programmed cell death, crucial for maintaining tissue homeostasis and eliminating damaged or unwanted cells. It involves a complex interplay of pro-apoptotic and anti-apoptotic signaling pathways, ultimately leading to the activation of caspases and the characteristic morphological changes associated with apoptosis.
**Why the Correct Answer is Right**
The correct answer is **B. Bcl-2**. Bcl-2 (B-cell lymphoma 2) is a key anti-apoptotic protein that inhibits apoptosis by binding to and neutralizing pro-apoptotic proteins, such as Bax and Bak. Bcl-2 achieves this by preventing the mitochondrial outer membrane permeabilization (MOMP), which is a critical step in the apoptotic cascade. By blocking MOMP, Bcl-2 allows the cell to bypass the pro-apoptotic signals and survive.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a known inhibitor of apoptosis.
**Option C:** This option is incorrect because it is not directly related to the inhibition of apoptosis.
**Clinical Pearl / High-Yield Fact**
Bcl-2 is often overexpressed in various cancers, leading to uncontrolled cell growth and resistance to chemotherapy-induced apoptosis. This highlights the importance of understanding the molecular mechanisms underlying apoptosis in the context of cancer biology.
**Correct Answer: B. Bcl-2**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.